> For the complete documentation index, see [llms.txt](https://docs.owkin.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.owkin.com/what-you-can-do-with-k-pro/trial-navigator.md).

# Indication prioritization & target validation

Use K Pro to assess whether a target is worth advancing, and to validate that biomarkers behave consistently across data modalities.

* **Assess target tractability & druggability**: evaluate target tractability, safety profiles, and therapeutic potential using curated databases.
* **Validate biomarkers across modalities**: test biomarkers and hypotheses across bulk RNA-seq, single-cell, spatial, and clinical data.

**What to do:** Combine multiple data modalities (RNA-seq, mutation data, etc.) within a cohort to identify candidates that show convergent evidence across layers. Multiomics queries are computationally intensive: start with a specific comparison (two subgroups) rather than "analyze everything."

**Example prompt:**

> In the TCGA-BRCA cohort, integrate RNA-seq gene expression and mutation data. Identify genes that are both differentially expressed and frequently mutated in basal-like versus luminal A patients.

**Expected result:** A multi-omics integration result showing genes that appear significant across both data modalities.

**Follow-up:**

> Perform an individual gene expression comparison of MSIGDB DNA repair, oxidative stress, and EMT pathway signatures at Bulk RNA level using a violin plot with p-values comparing Basal-like and Luminal TCGA-BRCA patients.

{% embed url="<https://vimeo.com/1183008489?amp;fe=ci&amp;fl=sv&share=copy>" %}


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# Agent Instructions
This documentation is published with GitBook. GitBook is the documentation platform designed so that both humans and AI agents can read, navigate, and reason over technical content effectively. Learn more at gitbook.com.

## Querying This Documentation
If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter, and the optional `goal` query parameter:

```
GET https://docs.owkin.com/what-you-can-do-with-k-pro/trial-navigator.md?ask=<question>&goal=<endgoal>
```

`ask` is the immediate question: it should be specific, self-contained, and written in natural language.
`goal` is optional and describes the broader end goal you are ultimately trying to accomplish on behalf of the user. GitBook uses it to tailor the answer towards what is most useful for that goal.

The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.