Changelog

January 2026

2026-01-15

Pathology MCP Explorer: Tile-Level Visualization

• Display tiles with overlay of cell predictions.

• 13 MCP tools total (up from 12)

2026-01-14

Improved chart formatting Chart titles and axis labels now use consistent capitalization across all visualizations.

December 2025

2025-12-31

Pathology MCP Explorer: Tile-Level Analysis

• Filter and sort individual tiles within a slide by any histomics feature.

• Get detailed statistics (mean, std, min, max, percentiles) for any feature across a cohort.

Guided Prompts — 7 pre-built prompts to help you get started:

• Refine patient stratification

• Visualize whole slide images

• Assess biomarker potential

• Export quantitative data

• Explore Pathology Explorer capabilities

• Visualize tiles with predictions

• Get cohort-level statistics

Improvements:

• Feature descriptions now link to detailed documentation.

• Better timeout handling for large slide operations.

• 12 MCP tools total (up from 9)

2025-12-30

PDF report export Reports can now be downloaded as PDF files for easy sharing and archiving.

Bulk vs. spatial transcriptomics concordance New visualization compares bulk RNA-seq with spatial transcriptomics expression for the same genes.

Gene expression stratification in survival analysis Kaplan-Meier plots now support patient stratification by bulk gene expression levels (high vs. low expressors).

Resolved visualization timeouts Gantt visualizations no longer time out on large datasets.

2025-12-17

MOSAIC V5 single-cell data Added V5 single-cell RNA-seq for colorectal cancer with improved UMAP dimensionality reduction computed at the indication level.

Enhanced visualization clarity Sankey and Gantt plots now include legends with consistent color coding. Sankey plots auto-prune less relevant pathways. Single-cell plots have improved colorbar layouts.

Improved spatial and single-cell plot accuracy Updated plot descriptions improve how K Pro interprets analysis requests.

Fixed Sankey plot grouping Corrected patient grouping errors in treatment pathway visualizations.

Fixed single-cell annotations Resolved cell type mapping errors.

2025-12-05

Treatment pathway visualization New Sankey diagrams show patient flows across lines of therapy with transitions and clinical responses.

Corrected volcano plot captions Captions now correctly display gene/protein counts instead of sample counts.

2025-12-01

Pathology MCP ExplorerInitial release.

• 9 MCP tools for histomics analysis

• Support for 6 cell types across TCGA cohorts

• Survival analysis with Kaplan-Meier curves

• Slide thumbnail visualization

• Histomics data download via presigned URLs

September 2025

2025-09-16

Cell expression percentages in spatial analysis Spatial transcriptomics now shows the percentage of cells expressing a target per patient, broken down by cell type.

Improved platform capability guidance K Pro now more accurately describes its own capabilities when asked.

2025-09-02

In-platform feedback button Added "Contact us" button for direct feedback and support requests.

Resolved multi-omics display errors Fixed visualization rendering issues.

August 2025

2025-08-07

MOSAIC datasets in data explorer MOSAIC datasets now appear on the Explore Data page for easier discovery.

Clearer product identification UI now clearly indicates which product you are using.

Improved multi-omics grouping Fixed cohort comparison reliability.

July 2025

2025-07-30

Explore Data tab New interface for browsing available datasets (TCGA, MOSAIC Window) before starting analyses.

Advanced filtering and grouping Filter on any indication-specific clinical variable. Group patients by histomics variables such as cell density from H&E images.

MOSAIC V5.3 release Added clinical variables and manual annotations for the full MOSAIC cohort.

2025-07-12

Sample-level multi-omics analysis Plots can now be generated at the sample level to reveal intra-patient heterogeneity.

2025-07-03

Gene signature support across all plot types All visualizations now support custom multi-gene signatures. Define pathway-level scores (e.g., [PTGS2, PTGES, PTGES2, PTGES3]) and analyze combined expression.

June 2025

2025-06-20

Single-cell co-expression analysis New dotplot visualizes gene pair co-expression at single-cell resolution with Jaccard index scoring.

Chat session deletion Delete individual sessions for better organization.

Gene signature support (initial release) Bulk violin, stratified violin, and UMAP plots now support gene signatures.

Suggested prompts Landing page now shows example queries for faster onboarding.

Fixed bulk RNA-seq calculations Corrected log2(TPM+1) transformation errors.

Improved population summaries Resolved demographic table display issues.

Questions or feedback? Contact [email protected]