# Changelog

### May 2026

### 2026-05-20

**Pathology Explorer**: flexible cohort name formats Pathology Explorer tools now accept both TCGA-LUAD and TCGA\_LUAD cohort name formats, preventing silent tool call failures when the standard hyphenated format is used.

**Multi-omics**: corrected oncogenic variant handling Mutation frequency analysis now correctly treats the oncogenic column as a boolean flag, fixing plots that previously misgrouped oncogenic vs. non-oncogenic variants.

**Login reliability:** Resolved a rare login loop that could occur when multiple authentication requests fired in parallel.

#### 2026-05-06

**Prior Knowledge Database: Tool Restored** Fixed an outage affecting the Bioknowledge Navigator / Prior Knowledge Database tool that prevented queries against curated knowledge sources between late April and early May. Authentication to underlying data has been hardened to prevent recurrence.

**Claude 4.x Model Upgrade** All K-Pro services (Bioknowledge Navigator, Multi-Omics, orchestration) now run exclusively on Claude 4.x. Earlier Sonnet 3 / 3.5 / 3.7 and Haiku 3 references have been deprecated, providing more capable reasoning across the platform.

### April 2026

#### 2026-04-28

**Consensus Replaces Literature Review** A new evidence search tool, Consensus, is now live for K-Pro Free users. Compared to the previous Literature Review service: significantly wider research article coverage, with most articles accessible as full text rather than abstracts only; new filters for recency (e.g. publications from the last year) and top-tier journals. The Explore Data tab now points to Consensus as the literature source.

#### 2026-04-27

**Improved Agent Reasoning for K-Pro Free** K-Pro Free users now run on a next-generation agentic pipeline with flat orchestration. The new pipeline streamlines how queries are routed across tools, producing more direct, consistent answers — especially for multi-step clinical questions. Plotter generation has been updated in parallel: cleaner clinical summaries, better population plots, and improved alignment between the data you ask about and the visualization returned.

**Onboarding Refresh** The post-login onboarding experience has been redesigned with a single-video modal and a new onboarding quiz that captures user persona for tailored prompt suggestions. Both new and returning users see the redesign.

**Personalized Suggested Prompts** Suggested prompts on the chat landing page are now personalized based on user persona, surfacing more relevant starter queries.

**Longer Conversations Stay Coherent** New context compaction automatically summarises older conversation history when approaching the token limit, preserving context across long analytical sessions.

**Pathology Explorer: GigaTIME Immune Biomarker Features** New tools expose GigaTIME virtual multiplex immunofluorescence (mIF) data for TCGA-LUAD: 21 mean channel expression values per slide via `get_gigatime_features`, marker grid display via `display_gigatime_map`, and HE-vs-marker side-by-side overlays via `display_gigatime_overlay`. Survival analysis and cohort description tools have been extended to support categorical Kaplan-Meier stratification on Gigatime data.

#### 2026-04-09

**Streaming Responses** Agent responses now stream in real time as they are generated, reducing perceived latency for long answers.

**Explore Data: More Datasets and Refined Filters** Additional datasets are now surfaced in the Explore Data tab, with refined display and filtering for inclusion/exclusion (I/E) criteria.

**MOSAIC Data Access Clarity** K-Pro now correctly explains MOSAIC data access: only MOSAIC Window (a 60-patient public subset) is hosted on EGA. Access to the full MOSAIC dataset requires a data licensing conversation with Owkin.

#### 2026-04-03

**TA-Aware Population Plots** Clinical summaries now adapt to the dataset's Therapeutic Area. Oncology queries surface a clinical summary table, an indication-specific summary, and Kaplan-Meier curves for Overall Survival (OS) and Progression-Free Survival (PFS). Immunology & Inflammation studies (Crohn's disease, UC) display a clinical summary table alongside a sample-level disease activity score summary and biopsy site information.\
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**Authentication Upgrade:** Login flows have been migrated from Amplify to a standard OIDC protocol, improving security and reliability. Microsoft Entra ID is now supported as an identity verifier for enterprise environments.\
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**Chat History: Infinite Scrolling** The chat history page now supports infinite scrolling for easier navigation through long conversation histories.

### March 2026

#### 2026-03-20

**Therapeutic-Area-Aware Clinical Summaries** Clinical summaries now automatically select the most relevant plots based on the therapeutic area — Kaplan-Meier curves for oncology, variable descriptions for immunology and inflammation datasets.

**Variant-Level Table** A new variant-level table is now available in multi-omics analyses, enabling exploration of genomic variant data at the individual variant level.

**Procedure Event Table** Patient procedure events are now available as a dedicated table, expanding the clinical data accessible for analysis.

#### 2026-03-02

**K Data Catalog: Improved Dataset Discovery** Enhanced dataset metadata and improved navigation make it easier to explore and understand available datasets directly from the platform.

**Multi-Omics: Cross-Center Cohort Grouping** Multi-center cohorts can now be grouped at the indication level, removing center-level fragmentation for cleaner population-level analyses.

***

### February 2026

#### 2026-02-18

**Clinical Summaries: Multi-Dataset Queries Fixed** Resolved an issue preventing clinical summaries from querying across multiple datasets in a single session.

#### 2026-02-12

**Improved PDF Report Export** Reports now render special characters correctly and plots are placed in order for more accurate exports.

***

### January 2026

#### 2026-01-15

**Pathology MCP Explorer: Tile-Level Visualization**

* Display tiles with overlay of cell predictions.
* 13 MCP tools total (up from 12)

#### 2026-01-14

**Improved chart formatting** Chart titles and axis labels now use consistent capitalization across all visualizations.

### December 2025

#### 2025-12-31

**Pathology MCP Explorer: Tile-Level Analysis**

* Filter and sort individual tiles within a slide by any histomics feature.
* Get detailed statistics (mean, std, min, max, percentiles) for any feature across a cohort.

**Guided Prompts** — 7 pre-built prompts to help you get started:

* Refine patient stratification
* Visualize whole slide images
* Assess biomarker potential
* Export quantitative data
* Explore Pathology Explorer capabilities
* Visualize tiles with predictions
* Get cohort-level statistics

Improvements:

* Feature descriptions now link to detailed documentation.
* Better timeout handling for large slide operations.
* 12 MCP tools total (up from 9)

#### 2025-12-30

**PDF report export** Reports can now be downloaded as PDF files for easy sharing and archiving.

**Bulk vs. spatial transcriptomics concordance** New visualization compares bulk RNA-seq with spatial transcriptomics expression for the same genes.

**Gene expression stratification in survival analysis** Kaplan-Meier plots now support patient stratification by bulk gene expression levels (high vs. low expressors).

**Resolved visualization timeouts** Gantt visualizations no longer time out on large datasets.

#### 2025-12-17

**MOSAIC V5 single-cell data** Added V5 single-cell RNA-seq for colorectal cancer with improved UMAP dimensionality reduction computed at the indication level.

**Enhanced visualization clarity** Sankey and Gantt plots now include legends with consistent color coding. Sankey plots auto-prune less relevant pathways. Single-cell plots have improved colorbar layouts.

**Improved spatial and single-cell plot accuracy** Updated plot descriptions improve how K Pro interprets analysis requests.

**Fixed Sankey plot grouping** Corrected patient grouping errors in treatment pathway visualizations.

**Fixed single-cell annotations** Resolved cell type mapping errors.

#### 2025-12-05

**Treatment pathway visualization** New Sankey diagrams show patient flows across lines of therapy with transitions and clinical responses.

**Corrected volcano plot captions** Captions now correctly display gene/protein counts instead of sample counts.

#### 2025-12-01

**Pathology MCP ExplorerInitial release.**

* 9 MCP tools for histomics analysis
* Support for 6 cell types across TCGA cohorts
* Survival analysis with Kaplan-Meier curves
* Slide thumbnail visualization
* Histomics data download via presigned URLs

### September 2025

#### 2025-09-16

**Cell expression percentages in spatial analysis** Spatial transcriptomics now shows the percentage of cells expressing a target per patient, broken down by cell type.

**Improved platform capability guidance** K Pro now more accurately describes its own capabilities when asked.

#### 2025-09-02

**In-platform feedback button** Added "Contact us" button for direct feedback and support requests.

**Resolved multi-omics display errors** Fixed visualization rendering issues.

### August 2025

#### 2025-08-07

**MOSAIC datasets in data explorer** MOSAIC datasets now appear on the Explore Data page for easier discovery.

**Clearer product identification** UI now clearly indicates which product you are using.

**Improved multi-omics grouping** Fixed cohort comparison reliability.

### July 2025

#### 2025-07-30

**Explore Data tab** New interface for browsing available datasets (TCGA, MOSAIC Window) before starting analyses.

**Advanced filtering and grouping** Filter on any indication-specific clinical variable. Group patients by histomics variables such as cell density from H\&E images.

**MOSAIC V5.3 release** Added clinical variables and manual annotations for the full MOSAIC cohort.

#### 2025-07-12

**Sample-level multi-omics analysis** Plots can now be generated at the sample level to reveal intra-patient heterogeneity.

#### 2025-07-03

**Gene signature support across all plot types** All visualizations now support custom multi-gene signatures. Define pathway-level scores (e.g., `[PTGS2, PTGES, PTGES2, PTGES3]`) and analyze combined expression.

### June 2025

#### 2025-06-20

**Single-cell co-expression analysis** New dotplot visualizes gene pair co-expression at single-cell resolution with Jaccard index scoring.

**Chat session deletion** Delete individual sessions for better organization.

**Gene signature support (initial release)** Bulk violin, stratified violin, and UMAP plots now support gene signatures.

**Suggested prompts** Landing page now shows example queries for faster onboarding.

**Fixed bulk RNA-seq calculations** Corrected log2(TPM+1) transformation errors.

**Improved population summaries** Resolved demographic table display issues.

Questions or feedback? Contact <support@owkin.com>


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