Trial Navigator

Overview

Trial Navigator is a specialized tool within Owkin K designed to help pharmaceutical professionals analyze the clinical trial landscape. It transforms natural language questions into powerful visualizations and structured insights, enabling you to:

• Map competitive landscapes across therapeutic areas

• Track competitor pipelines and development timelines

• Analyze trial design assumptions for individual studies

Trial Navigator automatically interprets your questions and delivers the appropriate analysis, whether you need a broad market overview or a deep-dive into a specific trial’s statistical assumptions.

Tips for effective queries:

• Be specific about the therapeutic area, indication, or mechanism of action

• Mention specific sponsors, drugs, or NCT IDs when relevant

• Specify trial phases if you want to focus on a particular development stage

• Include timeframes (e.g., “trials that started after 2020”) to narrow results

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Key capabilities

Competitive landscape analysis

Get a visual timeline of clinical trials across any therapeutic area, mechanism of action, or competitive set.

What you get:

• Interactive gantt chart showing trial phases and timelines

• Detailed results table with all matching trial metadata

• Summary statistics (enrollment totals, sponsor counts, phase distribution)

• Direct links to ClinicalTrials.gov for each trial

Example queries:

"What are the trials targeting ERBB2 for breast cancer?"
"Show me Phase III immunotherapy trials in NSCLC"
"List clinical trials for Alzheimer's disease involving gene therapy"
"What trials is Pfizer running in melanoma?"
"Show me all ADC trials that started after 2022"

Single trial statistical analysis

Deep-dive into the statistical assumptions underlying any specific trial’s design and projected readout times.

What you get:

• Statistical projection plot showing enrollment and survival curves

• Predicted median OS and PFS based on historical data

• Predicted enrollment duration estimates

• Reference trials used to generate predictions

Example queries:

"Perform a statistical analysis for trial NCT04589845"
"What are the underlying assumptions for readout times of trial NCT04589845?"
"Show me the statistical projection plot for the NCT04589845 trial"

See it in action

Output formats

Gantt chart view

The timeline visualization displays:

• X-axis: Time (years)

• Y-axis: Individual trials (grouped by phase, sorted by start date)

• Bars: Represent trial duration with phase progression markers

Table view

A sortable, filterable table containing:

• NCT ID (with link to ClinicalTrials.gov)

• Sponsor information

• Phase, indication and drug information

• Key results

Summary statistics

Automatically computed metrics and answer summary that can include for example:

• Total trial count matching your query

• Phase distribution breakdown

• Top indications represented

Statistical projection

Interactive plotly visualization including:

• Data points: Enrollment curve, survival projections

• Reference trials: NCT ID used for predictions

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Searchable data fields

Trial Navigator provides access to a comprehensive clinical trials dataset. You can filter and search across the following dimensions:

Identification

Field	Description
NCT ID	ClinicalTrials.gov identifier
Brief Title	Short trial title
Official Title	Full formal trial title
Commercial Name	Sponsor’s commercial trial name

Status & Timeline

Field	Description
Overall Status	Recruiting, Active Not Recruiting, Completed, Terminated, etc.
Trial Start Date	Date the trial began
Primary Completion Date	Date of primary outcome measurement
Completion Date	Full study completion date
Trial Duration	Duration in days

Design

Field	Description
Study Type	Interventional, Observational
Trial Phase	I, II, III, IV, I/II, II/III, III/IV
Randomization	Whether the trial is randomized
Number of Arms	Count of treatment arms
Group Types	Experimental, Active Comparator, Placebo Comparator, etc.

Sponsors

Field	Description
Private/Industry Sponsors	Pharmaceutical and biotech companies (Pfizer, Roche, AstraZeneca, etc.)
Public/Academic Sponsors	Universities, hospitals, research centers, government agencies
Industry Sponsored	Boolean flag for industry involvement

Enrollment & accrual

Field	Description
Enrollment	Number of participants
Accrual Target	Target number of subjects
Accrual Actual	Actual enrolled subjects
Enrollment Duration	Time to complete enrollment (days)

Geography

Field	Description
Trial Countries	Countries where the trial is conducted
Trial Regions	Regions (North America, Western Europe, Asia, etc.)
Number of Sites	Count of trial sites

Eligibility criteria

Field	Description
Gender	Both, Female Only, Male Only
Age Range	Minimum and maximum age for eligibility
ECOG Status	Performance status requirements (0-4 scale)
Disease Stages	Localized, locally advanced, advanced, metastatic, resectable, unresectable
Disease Paths	Persistent, recurrent, refractory, relapsed, resistant
Lines of Therapy	Prior treatment requirements

Indications (cancer types)

Trial Navigator covers a comprehensive oncology landscape including:

Solid Tumors:

• Breast, Lung (NSCLC, SCLC), Colorectal, Pancreas

• Melanoma, Renal, Bladder, Prostate

• Head/Neck, Esophageal, Gastric, Liver

• Ovarian, Endometrial, Cervical

• CNS tumors (Glioblastoma, Astrocytoma, Meningioma, etc.)

• And many more…

Hematological Malignancies:

• Leukemia (ALL, AML, CML, CLL)

• Lymphoma (Hodgkin’s, Non-Hodgkin’s)

• Multiple Myeloma

• Myelodysplastic Syndrome

• Myeloproliferative Neoplasms

Treatment & intervention

Field	Description
Drug Names	Investigational drug names
Drug Type	ADC, Antibody Bispecific, Antibody Multispecific, Gene Therapy, Small Molecule
Mechanisms of Action	JAK inhibitor, CDK inhibitor, PD-1/PD-L1 inhibitor, etc.
Targets (HGNC)	Gene symbols (KRAS, TP53, BRCA1, EGFR, ERBB2, etc.)
Biomarkers	Biomarkers used in trial selection
Combination Therapy	Whether the trial tests a drug combination

Endpoints

Field	Description
Primary Endpoints	OS, PFS, DUAL, or other
Has OS	Overall Survival as endpoint
Has PFS	Progression-Free Survival as endpoint
Has EFS/DFS/RFS	Event-free, Disease-free, Recurrence-free Survival

Outcomes (actual & predicted)

Field	Description
Objective Response Rate	ORR from trial results
Disease Control Rate	DCR from trial results
Median OS (months)	Actual median overall survival
Median PFS (months)	Actual median progression-free survival
Predicted Median OS	AI-predicted median OS
Predicted Median PFS	AI-predicted median PFS
Predicted Enrollment Duration	AI-predicted time to complete enrollment

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Query examples by use case

Competitive Intelligence

Map the competitive landscape for a target:

"Show me all trials targeting HER2 in breast cancer"
"What trials are investigating KRAS G12C inhibitors?"
"List all PD-1/PD-L1 trials in NSCLC since 2020"

Track competitor pipelines:

"What Phase III trials is Merck running in oncology?"
"Show me Roche's ADC pipeline across all indications"
"List all trials sponsored by BioNTech in solid tumors"

Analyze mechanism trends:

"Show me all bispecific antibody trials in hematological malignancies"
"What gene therapy trials are active in oncology?"
"List all CAR-T trials recruiting in the US"

Portfolio management

Assess development timelines:

"Statistical analysis for NCT04589845"
"What are the projected readout dates for trial NCT04589845?"

Compare trial designs:

"Show me Phase III trials in 1L metastatic NSCLC with OS as primary endpoint"
"What trials are testing combinations with pembrolizumab in melanoma?"

Identify white space opportunities:

"What Phase II trials are there in cholangiocarcinoma?"
"Show me trials in myelodysplastic syndrome that started after 2021"

Clinical development strategy

Benchmark enrollment assumptions:

"What is the typical enrollment for Phase III NSCLC trials?"
"Show me completed trials in breast cancer with enrollment over 500 patients"

Analyze endpoint selection:

"What trials use dual OS/PFS endpoints in gastric cancer?"
"Show me Phase III trials with PFS as primary endpoint in ovarian cancer"

Understand eligibility trends:

"What trials require ECOG 0-1 in metastatic colorectal cancer?"
"Show me trials enrolling patients with prior immunotherapy in melanoma"

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Advanced Features

Comparative Queries

Trial Navigator can handle queries that compare against specific trial values:

"Show me trials that started after trial NCT04589845"
"Find trials with higher enrollment than NCT04589845"
"What trials have longer duration than the NCT04589845 study?"

The system automatically looks up the reference trial’s values and uses them to filter results.

Multi-Step Analysis

For complex queries requiring multiple data lookups, Trial Navigator orchestrates the analysis automatically:

"For the top 3 trials by enrollment in lung cancer, show their statistical projections"

The system will:

1. Find the top 3 trials by enrollment

2. Extract their NCT IDs

3. Generate statistical projections for each

Smart Name Resolution

Trial Navigator understands synonyms and variations:

• “Keytruda” maps to pembrolizumab

• “Herceptin” maps to trastuzumab

• Various gene name formats (ERBB2/HER2/neu)

• Sponsor name variations (Merck & Co., MSD, Merck Sharp & Dohme)

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Limitations

• Data scope: Primarily oncology-focused; coverage in other therapeutic areas may vary

• Statistical projections: Available only for Phase II and III trials with sufficient historical data

• Data freshness: Dataset is updated periodically; for real-time status, verify on ClinicalTrials.gov